PEP/NEWS — Peptide intel. Daily.

Elad Gil is CEO of Gil & Co, a multi-stage investment firm, holding company, and operating company working on the world’s most advanced technologies. Elad is a serial entrepreneur, operating executive, and investor or advisor to private com

I used to weigh 300 pounds. I tried every restrictive diet, became a vegan, and trained 90 minutes a day for 18 months with absolute zero results. Everything changed when I drank a cup of yak butter tea at 18,300 feet in Tibet. Within 30 se

Researchers used fiber photometry to record kisspeptin (a reproductive signaling peptide) neuron activity across the full estrous cycle in female mice. A sustained firing burst preceded each luteinizing hormone surge. The data clarifies how kisspeptin drives ovulation — with implications for reproductive peptide research.

Rockefeller University professor Junyue Cao discusses his lab's ultra-high-throughput single-cell work published in Science. His team mapped aging across tissue types at cellular resolution — building the kind of atlas that peptide researchers will use to find high-value intervention targets.

In mice, a period of obesity left T cells stuck in a pro-inflammatory state — even after normal weight returned. The finding adds pressure on metabolic peptide strategies: GLP-1 class drugs may drive weight loss, but immune memory of obesity may require additional intervention.

The first trial combining rapamycin with structured exercise returned underwhelming results. Attia breaks down why a single negative trial doesn't close the book on rapamycin as a longevity tool — and what would make future trials more informative.

A reference map covering known synergies and potential conflicts between commonly researched peptides. Useful for anyone designing multi-peptide protocols in a lab context — covers receptor competition, pathway overlap, and timing considerations.