PEP/NEWS — Peptide intel. Daily.

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In this video, Dr. Rena Malik explains why 82% of women can’t reliably orgasm from intercourse alone and what’s actually missing during sex. She breaks down the real anatomy of the clitoris, why in-and-out thrusting often fails, and the res

Dr. Kentaro Fujita, PhD, is a professor of psychology at The Ohio State University and an expert in the science of self-control and motivation. We discuss the best tools for developing strong self-control: to do more of what you aspire to a

New research suggests T cells (immune cells that regulate inflammation) retain a pro-inflammatory state long after a period of obesity ends — even once weight returns to normal. In mice, the effect lasted weeks. The human duration is still unknown.

A new Aging Cell paper maps how the aging gut allows harmful bacteria to gain ground. Researchers found that intestinal aging causes transcriptional changes — shifts in how genes are read — that impair the gut's immune defenses. The gut-barrier angle has direct relevance to peptides studied for GI protection.

Johnson tested his home environment and found toxins across multiple vectors — air particles, water contaminants, and cookware chemicals. He outlines 14 concrete steps he took. It's a practical environmental-load reduction framework for anyone focused on longevity.

New evidence shows muscle stem cells aren't simply worn out with age — they're suppressed by the environment around them. When old stem cells are removed from aged tissue and tested alone, they still function. The finding points to the tissue environment, not the cells themselves, as the primary target.

The first trial combining rapamycin with exercise produced weaker results than expected. Attia breaks down why one negative trial doesn't end the conversation on rapamycin as a potential geroprotector — and what the data actually showed.

Researchers reproduced sleep apnea-like intermittent oxygen drops in mice and found it raised the burden of senescent cells (damaged cells that drive inflammation) in vascular tissue. The link between disrupted breathing, cellular senescence, and cardiovascular risk is now more mechanistically grounded.

A new Aging Cell paper found that exercise releases eNAMPT (a NAD-related enzyme) packaged in exosomes (tiny cellular messengers). These activate SIRT1 (a longevity-linked protein) in the liver and reduce age-related fat buildup and scarring. It's a molecular explanation for why exercise protects the aging liver.

A new Aging Cell review argues melatonin should be seen as an active repair agent for testosterone decline — not just a sleep aid. It targets senescent Leydig cells (the testicular cells that make testosterone) and may help restore function rather than just supplement around the deficit.

Brain imaging data show menopause triggers neurological changes that go well beyond reproductive function. Attia's piece reviews how estrogen shifts affect cognition, metabolism, and brain structure — and why this matters for anyone tracking hormonal optimization.

Lifespan.io's monthly roundup covers advocacy, funding, and research milestones across the longevity field in April 2026. A useful single-source digest of what moved the needle last month.

APOE2 (a rare gene variant linked to exceptional longevity) appears to protect neurons from senescence by activating DNA repair signaling. The study adds mechanistic detail to why APOE2 carriers age better — and points to potential therapeutic targets.