PEP/NEWS — Peptide intel. Daily.

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In this video, Dr. Rena Malik explains why 82% of women can’t reliably orgasm from intercourse alone and what’s actually missing during sex. She breaks down the real anatomy of the clitoris, why in-and-out thrusting often fails, and the res

Dr. Kentaro Fujita, PhD, is a professor of psychology at The Ohio State University and an expert in the science of self-control and motivation. We discuss the best tools for developing strong self-control: to do more of what you aspire to a

A new study found creatine supplementation added to the muscle-protective benefits of power training in older adults. The combination outperformed exercise alone on several markers — relevant data for anyone tracking anabolic support strategies.

Researchers mapped the link between intestinal aging and gut microbiome shifts in Aging Cell. As the gut lining ages, it loses the ability to police microbial populations — and harmful strains move in. The gut-brain axis and peptide research both hinge on this biology.

Rockefeller professor Junyue Cao builds ultra-high-throughput single-cell tools and applies them to aging biology. His recent Science paper maps how different cell types age at different rates — foundational data for peptide and longevity researchers.

Attia's latest AMA covers NAD supplementation alongside metabolic health markers, strength training efficiency, and dementia risk. It's a useful companion to his earlier peptide AMA for anyone building a full optimization picture.

Researchers induced the intermittent hypoxia of sleep apnea in mice and found it sharply raises senescent cell burden in vascular tissue. The finding adds a cellular mechanism to explain why untreated sleep apnea tracks so closely with cardiovascular disease.

Chronic inflammation from an aged immune system accelerates neurodegenerative damage. The review points to inflammaging — the low-grade immune overactivation of old age — as a central mechanism, not a side effect.

The APOE2 variant — linked to exceptional longevity — appears to activate DNA signaling pathways that help neurons resist senescence. The finding opens a new angle on why APOE2 carriers age better neurologically.

T cells may hold a pro-inflammatory memory long after weight is regained following obesity. The mouse data suggest metabolic history leaves a lasting immune imprint — relevant context for GLP-1 research and post-weight-loss health.