PEP/NEWS — Peptide intel. Daily.

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A new study found creatine stacked on top of power training added benefits that neither produced alone in older adults. Creatine remains one of the best-studied compounds for preserving muscle with age — and this trial gives the combo a cleaner signal.

Brain health experts make the case that cognitive decline is far more reversible and preventable than the mainstream narrative suggests. The piece outlines the modifiable drivers — and where peptide-adjacent interventions fit into the picture.

New brain imaging data suggest menopause is not just a reproductive event — it reshapes brain physiology in measurable ways. The findings have direct implications for hormone optimization strategies and cognitive longevity.

Researchers modeled sleep apnea-style hypoxia in mice and found it sharply raised the burden of senescent cells (aged, damage-signaling cells that won't clear themselves) in vascular tissue. The data draw a cleaner mechanistic line between interrupted breathing at night and accelerated arterial aging.

Using fiber photometry in mice, researchers recorded kisspeptin (a peptide that triggers the reproductive hormone cascade) neuron activity across the full estrous cycle. They found a prolonged oscillating burst drives the LH surge that triggers ovulation — adding mechanistic detail that matters for reproductive peptide research.

Rockefeller University's Junyue Cao explains how ultra-high-throughput single-cell sequencing is building a tissue-by-tissue map of biological aging. Understanding which cell types age fastest — and why — is foundational for targeting peptide interventions precisely.

Researchers found that controlled hypoxia (low-oxygen stress) triggers autophagy — the cell's self-cleanup system — to degrade HIF-1α, a protein that normally builds up with age. The result was reduced cellular aging and extended lifespan in mammalian models, pointing to a druggable pathway.

Bryan Johnson tested his home and found microplastics, airborne particles, and chemical exposures throughout. He details 14 specific changes — some free — aimed at reducing the environmental load that compounds biological aging.