Creatine augments power training adaptations in older adults beyond what exercise alone delivers.
— Lifespan.io
Peptide intel. Daily.
Creatine augments power training adaptations in older adults beyond what exercise alone delivers.
— Lifespan.io
In AMA #84, Attia tackles NAD+ supplementation alongside cardiovascular risk, metabolic health, and strength training efficiency — a rare episode that directly engages the peptide-adjacent supplement stack most serious optimizers are running. Essential listening for anyone calibrating their longevity protocol.
Peter Attia
The first prospective trial combining rapamycin with exercise failed to show additive benefit, a result Attia dissects carefully without abandoning the geroprotector hypothesis. A masterclass in how to read a negative trial without overcorrecting.
Peter Attia
The widely self-experimented dasatinib + quercetin senolytic stack causes damage in specific brain regions in mice, according to a new study. The finding doesn't invalidate the senolytic category but demands more granular safety data before human protocols become routine.
Lifespan.ioRather than simply supplementing testosterone, researchers propose melatonin may actively repair age-related dysfunction in Leydig cells — the testicular cells that produce testosterone. The shift from passive hormonal replacement to cellular repair has obvious implications for how late-onset hypogonadism is managed.
Aging CellPlasma dilution — the removal of aged circulating factors — following myocardial ischemia-reperfusion injury significantly improved cardiac repair, heart performance, and functional recovery in old mice. The data continue to build the case that aged blood composition is itself a therapeutic target.
Aging Cell
T cells may retain a pro-inflammatory phenotype long after normal weight is restored following obesity, with mouse data showing the effect persisting for weeks. This metabolic immune memory concept changes how we should think about recovery timelines post-weight loss — and what adjunct therapies might be needed.
Lifespan.ioThe $3 billion partial reprogramming venture Altos Labs is emerging from near-total secrecy, with leadership apparently seeking to shape the public narrative around cellular rejuvenation science. Fight Aging! provides useful context on the state of the field and what the PR push likely signals.
Fight Aging!
New research finds that more vigorous transient senescent cell activation — not less — correlates with better wound healing in younger mice, complicating the simple narrative that all senescence is bad. Context and timing of senolytic interventions may matter more than previously appreciated.
Lifespan.io
Johnson's Blueprint team reviews the evidence base for skin aging interventions — separating ingredients with mechanistic backing from the noise of overpromised creams. Relevant background for anyone tracking GHK-Cu or peptide-based topical research.
BluePrint (Bryan Johnson)
The Longevity Investor Network's retrospective on 2025 maps where institutional capital flowed in the aging-research ecosystem — a useful read for tracking which therapeutic categories are attracting serious funding versus staying stuck in preclinical purgatory.
Lifespan.ioA Nature Aging perspective argues the aging extracellular matrix — not just the cells within it — drives senescent cell persistence, reframing where therapeutic intervention might be most effective.
Nature AgingAnalysis of the exoproteome in calorically restricted humans reveals complement system deactivation as an immunometabolic checkpoint — a potential mechanistic bridge between calorie restriction and reduced systemic inflammation.
Nature Agingp21+TREM2+ senescent macrophages are identified as key drivers of both systemic inflammaging and metabolic dysfunction-associated steatotic liver disease, offering a cellular target for next-generation senolytic strategies.
Nature AgingAGEs suppress SIRT1 expression, activating RANKL-driven osteoclast activity and chondrocyte senescence — a finding that links dietary glycation products directly to osteoarthritis progression.
Aging CellNew data show that transplanting aged gut microbiota induces sweeping mucosal transcriptional dysfunction in recipients, with downstream impairment of immune surveillance — strengthening the gut-aging-immunity axis.
Aging CellVitamin K2 extends worm lifespan by alleviating mitochondrial stress through a conserved longevity signaling axis — adding mechanistic detail to what has historically been correlation-based supplementation data.
Aging Cell