PEP/NEWS — Peptide intel. Daily.

EP. 261: Get Strong with Me Inside my NEW Strength Vault: ⁠https://www.drtyna.com/offers/G33fSdvS/checkout In this episode, I sit down with Dr. Amy Hornaman to go deep on thyroid dysfunction, Hashimoto’s, and why so many people are misdiag

Jerzy Gregorek is a 4x World Weightlifting Champion, co-founder of UCLA’s weightlifting team, and co-creator, with his wife Aniela, of the Happy Body program. You can watch Prisoner No More for free here: https://tim.blog/hardchoices. To fi

Prisoner No More follows Tae Jin Park, a young man diagnosed with cerebral palsy, who dismantled every physical limitation medical science predicted for him. Through athletic training under Olympian strength coach Jerzy Gregorek—and an unco

Cyclarity Therapeutics released Phase 1 results showing its cyclodextrin compound UDP-003 drives excretion of 7-ketocholesterol (7KC), a toxic oxidized lipid tied to cardiovascular damage. This is a direct-removal approach, not a reduction strategy.

Lifespan.io interviewed Cyclarity CEO Matthew O'Connor after the company's Phase 1 readout. He explains the case for targeting 7-ketocholesterol directly rather than managing downstream inflammation or LDL. Worth a read alongside the data release.

Forever Healthy released AI4L 1.0, an open-source tool designed to produce rigorous, evidence-based reviews of longevity interventions. It targets the gap between raw research and actionable interpretation — a useful reference layer for researchers tracking peptide literature.

New research finds that specific immune cells circulating in blood accelerate cognitive aging. Blocking those cells improved memory in animal models. The finding opens a potential peptide-accessible pathway for slowing age-related cognitive decline.

Bryan Johnson shares bone density data and the evidence linking skeletal health to mortality risk. In women over 65, higher bone density was tied to a 51% lower risk of death. Growth hormone axis peptides are among the compounds researchers study for bone preservation.

County-level data from 3,143 US locations ranks getting fewer than 7 hours of sleep as the third strongest predictor of shortened life — behind only smoking and obesity. Sleep peptides like DSIP (delta sleep-inducing peptide) continue to attract research interest in this context.

A new analysis finds that mainstream epigenetic clocks — built from blood cell DNA methylation — do not respond strongly to physical fitness levels. The finding raises questions about using current clock scores to evaluate lifestyle or peptide interventions.

A large epidemiological study finds that lifestyle and environment account for far more of late-life mortality risk than genetic variants do. For most people, behavior — including the interventions researchers study — matters more than inherited predisposition.