PEP/NEWS — Peptide intel. Daily.

Bryan Johnson reviews which skin-aging ingredients actually have evidence behind them and which don't. He tested dozens of products and built his own stack after finding most commercial anti-aging creams overpromise.

Bryan Johnson digs into the bone density literature. The numbers are striking: higher density associates with a 51% lower death risk in older women and a 23% lower risk in men aged 65–76. Bone health may be the most underrated longevity lever.

About 5% of the body's creatine stores live in the brain — not just muscle. Bryan Johnson reviews the evidence for cognitive benefits, which most gym-focused coverage ignores entirely.

Researchers publishing in Aging Cell map how age-related changes to the intestinal lining create conditions that favor harmful bacteria. The gut-immune feedback loop is a key target for longevity-focused peptide research.

Cyclarity Therapeutics releases Phase 1 excretion data for UDP-003. The drug targets 7-ketocholesterol (a toxic oxidized lipid linked to cardiovascular disease) rather than just lowering LDL. It's a root-cause approach most lipid trials don't attempt.

New county-level data from 3,143 US counties ranks getting under 7 hours of sleep as the third strongest predictor of a shorter life. Bryan Johnson breaks down the mechanisms and the habits that move the needle.

Scientists have found a way to sharply amplify mouse immune responses to cancer, flu, and COVID-19 using mRNA. The approach works by improving how T cells are primed — not by targeting the tumor directly.

Researchers find that the APOE2 variant — associated with exceptional longevity — helps human neurons resist cellular senescence through specific DNA repair signaling. It's a molecular clue about why some people age better neurologically than others.

A reference chart mapping known synergies and conflicts between commonly studied peptides. Multi-peptide stacking is increasingly common in research — this is the kind of resource that should precede any combination design.

A Fight Aging! analysis finds that physical fitness has a surprisingly weak effect on commonly used epigenetic clocks. The finding raises questions about what these tools are actually measuring — and how to interpret them in longevity research.