PEP/NEWS — Peptide intel. Daily.

In this video, Dr. Rena Malik explains the 5 biggest signs your pelvic floor might have a problem—from leaking when you laugh or sneeze to constant bathroom urgency, weaker orgasms, erectile issues, and trouble emptying your bladder or bowe

Most fasting videos tell you which method to use — but they skip the part that actually determines whether you keep losing weight or hit a wall. Because the real secret isn't which fasting method you pick, it's how often you do it. So in th

Use Code THOMAS20 for 20% off Your First Order of SEED: https://www.seed.com/thomasyt This video does contain a paid partnership with a brand that helps to support this channel. It is because of brands like this that we are able to provide

Bryan Johnson's team reviewed the evidence on skin aging and built a formulation around actives that actually had data. The post is worth reading for the filtering methodology — the products that didn't make the cut are as revealing as the ones that did.

Bone density predicts longevity independently of fracture risk — the data are clear on that. Bryan Johnson shares his own bone scan results and the interventions behind them. The longevity numbers cited (51% lower death risk in women over 65) are worth sitting with.

New county-level data ranks under 7 hours of sleep as the third strongest predictor of early death — behind only smoking and obesity. Bryan Johnson breaks down the levers most likely to extend deep sleep duration based on his own tracking and the published evidence.

Researchers mapped how intestinal aging changes the gut microbiome and undermines immune control in the intestinal lining. The two processes reinforce each other. Understanding the feedback loop is the first step toward breaking it.

Half of all hair loss goes unnoticed until it's visible — by which point significant follicle damage has already occurred. Bryan Johnson's team ranks the top five treatments by evidence strength. Useful for anyone tracking aesthetic optimization alongside other longevity work.

A pharmacovigilance analysis of FDA adverse event data examines the risk of delayed gastric emptying (slower stomach clearing) from GLP-1 receptor agonists. The concern is real enough that anesthesiologists now ask about GLP-1 use before surgery. The analysis puts scale on the signal.

Forever Healthy launched AI4L 1.0 — an open-source tool that uses frontier AI models to produce evidence-based reviews of longevity interventions. Accessible to anyone. The quality of the output will depend on the underlying evidence base, but the methodology is public and auditable.

Researchers found that priming aged skin with lipopolysaccharide (a bacterial product that triggers an immune response) before injury improved wound healing significantly. It's a surprising finding with no immediate clinical application — but it tells us something useful about how immune readiness connects to tissue repair.

Standard epigenetic clocks — built from immune cell DNA methylation data — appear to be poor sensors of physical fitness levels. That's a significant limitation for anyone using them as a fitness or intervention readout. The finding points to a gap in current biological age measurement tools.