PEP/NEWS — Peptide intel. Daily.

In this video, Dr. Rena Malik explains the real reasons men wake up multiple times a night to pee—and why it’s not always just your prostate. She breaks down the 4 most common causes of nighttime urination, including BPH, overactive bladder

What does it actually mean to be “enhanced”? As Day 2 of the Enhanced Games approaches, Dr. Alex Tatem takes a step back from world records, performance-enhancing drugs, and athletic competition to explore a bigger question: why do we acce

Virta Health founder Sami Inkinen details how nutritional and metabolic interventions reversed type 2 diabetes at scale. The conversation covers GLP-1 axis biology, insulin sensitivity, and what 100,000 patient outcomes actually look like in practice.

Beijing has rolled out the first national competency-based training program for physicians in longevity medicine. It is a structural signal: when a government of 1.4 billion people formalizes longevity as a medical specialty, the field's mainstream legitimacy accelerates.

Scientists built a CRISPR-based system that kills cells carrying a chosen RNA strand. Tested targets include cancerous and virus-infected cells — and the approach could eventually be tuned to clear senescent cells, a major goal in applied longevity research.

Bryan Johnson's Blueprint program publishes 12 evidence-cited behavioral changes for reducing screen-driven dopamine disruption and its downstream effects on sleep and metabolic health. The piece is practical and links each habit to a measurable biological rationale.

Johnson documents 14 interventions — from air quality monitoring to cookware swaps — based on home toxin testing. The focus on microplastics, forever chemicals, and particulate load connects to emerging research on environmental contributors to biological aging.

PLOS Biology researchers argue the field should move past debating whether adult neurogenesis exists and start finding ways to activate it. They outline strategies to harness endogenous stem cell potential in the hippocampus to build resilience against cognitive aging.

Fight Aging! covers new research showing that harmful microbes in the aging gut release extracellular vesicles — tiny signaling particles — that degrade tissue function systemically. The mechanism helps explain how gut dysbiosis drives systemic inflammation beyond the gut wall.

Boosting Sirtuin 6 (a protein that helps regulate which genes get read) reversed age-related changes to chromatin structure in liver cells. The finding supports Sirtuin 6 as a meaningful rejuvenation target, not just a correlate of aging.

Bryan Johnson's team reviews the evidence for creatine's cognitive effects, separate from its well-known role in muscle energy. About 5% of the body's creatine is stored in the brain — and that fraction may matter for memory and processing speed under stress.