PEP/NEWS — Peptide intel. Daily.

In this episode, Dr. Rena Malik, MD answers listener questions on this AMA ranging from blood in the urine and cystoscopy procedures to pain with sex after childbirth and challenges with achieving orgasm. She provides evidence-based advice

Tim Ferriss interviews Virta Health CEO Sami Inkinen on using technology and nutrition to reverse metabolic disease at scale. The dataset of 100,000+ patients makes this more than an anecdote.

Scientists found that phosphatidylcholine — the most common lipid in mitochondrial membranes — drops with age in worms, driving mitochondrial decline. The researchers suggest the same process may occur in humans.

Senolytic compounds (drugs that clear aged, dysfunctional cells) appear to protect dental pulp cells from age-related loss of maintenance capacity. It's an early finding, but senolytics keep showing up across unexpected tissues.

A PLOS Biology perspective argues that ovarian aging drives systemic decline across multiple organ systems — not just reproductive ones. The authors say ovarian aging belongs at the center of geroscience research.

Aged T cells secrete granzyme K, an enzyme that appears to damage neural tissue and impair cognition. Blocking it reversed the decline in animal models — adding immune aging to the list of reversible contributors to brain fog.

Researchers found that cutting methionine (an amino acid) extends yeast lifespan by triggering autophagy (cellular self-cleaning) through a pathway separate from nitrogen starvation. The finding clarifies how dietary methionine restriction may slow aging.

Rather than debating whether adult neurogenesis exists, researchers now argue for finding ways to activate the stem cell potential already present in the human hippocampus. The goal: build resilience against age-related cognitive decline.

Bryan Johnson reviews the evidence behind common skincare actives and finds most commercial products oversell their effects. The post outlines what the research actually supports for slowing visible skin aging.

Attia tackles the supplement evaluation problem directly: how do you tell if something is actually doing anything? The framework for avoiding false positives is more useful than any specific recommendation list.

Scientists show how early-stage cancer cells actively reshape neighboring tissue to create a niche favorable for tumor expansion. The finding opens a window for pre-metastatic intervention strategies.

Best known for its role in Alzheimer's pathology, tau turns out to be necessary for normal long-term memory formation. The finding complicates simple tau-clearance strategies for neurodegeneration.

Senescent microglia (aged brain immune cells) appear to be meaningful contributors to cognitive decline and neurodegeneration. Clearing them — or restoring their function — is now an active research target.