PEP/NEWS — Peptide intel. Daily.

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Attia's latest deep dive covers how sleep medications differ in onset, duration, and target — and why matching a drug's pharmacology to the specific sleep problem matters more than reaching for the same pill every night.

Despite a compelling mechanism, growth hormone has not delivered reliable results for adult tissue repair. Attia examines why the GH axis hasn't lived up to its musculoskeletal promise — and what the data actually show.

From lab-grown mini livers to engineered bile ducts, regenerative medicine is starting to reframe how we approach organ aging. The EASL 2026 conference showed that liver repair is no longer a distant idea.

A pilot study found that spermidine — a naturally occurring compound found in aged cheese and wheat germ — reduced markers of immune cell aging and improved vaccine response in healthy older adults. Small sample, but a clean signal worth watching.

Researchers found that Granzyme K — a protein secreted by aging T cells — contributes to cognitive decline. Blocking it reversed the effect in animal models. It's a new link between immune aging and brain function.

Senolytic therapies (drugs that clear aging cells) appear to help preserve dental pulp function in aging models. The finding adds to a growing list of tissues where clearing senescent cells has measurable effects.

Scientists found that phosphatidylcholine — the most common lipid in mitochondrial membranes — declines with age in worms and possibly humans. Restoring it in cell cultures improved mitochondrial function. Early stage, but a mechanistically clean finding.

A study published in the Journal of Clinical Apheresis found that therapeutic plasma exchange reduced microplastic particles in patient blood. Over 100 patients were tested before and after treatment. It's the first human data of its kind.

A new commentary argues that treating geroscience as a future luxury is a policy mistake. Public health systems remain in a reactive mode while longevity science is ready to move into prevention.

The third installment of Research Vials' cancer-and-peptides series tackles the trickiest question: what do GH secretagogues actually mean for cancer risk? It covers washout considerations and the evidence on both sides.