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The Ask DLG Show Episode #392 is streaming LIVE at 8:30 AM EST! Your health questions answered by DLG! 🌿 In case you missed it - Matcha + Moringa is BACK IN STOCK! - One of the most nutrient-dense plants on the planet - Helps you feel mo

Tom Dayspring is a world-renowned lipidologist and one of the most thoughtful teachers in the field of lipid metabolism. In this episode, Tom returns to The Drive for a deep dive into the relationship between lipids and brain health, beginn

A Lactobacillus strain in the gut releases chemical signals that enter the bloodstream and reduce fibrosis in the lungs of aged mice. The gut-lung axis finding builds on a growing body of work showing that microbiome composition shapes organ health well beyond the digestive tract.

Small molecule drugs that block PAI-1 — a protein tied to cellular senescence — are advancing in development. Humans with an inherited PAI-1 loss-of-function mutation live up to seven years longer than peers, giving researchers a compelling genetic rationale to target this pathway.

New findings reinforce that declining mitochondrial function in aging cells does more than cut energy output — it actively drives chronic inflammation. The mechanism involves mitochondrial DNA escaping into the cell body, where it triggers innate immune sensors.

The Forever Healthy Foundation publicly launched evipedia.ai, an open encyclopedia of evidence reviews covering more than 500 health and longevity interventions. Coverage includes first-generation rejuvenation therapies, supplements, and lifestyle protocols — all rated by evidence quality.

Researchers found a protein — conserved from yeast to humans — that helps cells destroy the core aggregate protein behind Parkinson's disease. Restoring this clearance pathway offers a new angle on a disease where protein buildup is the central problem.

Scientists found that boosting miR-330 — a regulatory molecule in cartilage and bone cells — can block the damage that excessive mechanical stress does to joints. The finding opens a potential molecular target for osteoarthritis prevention in high-load athletes and workers.

New preclinical data show that low-dose continuous rapamycin — rather than high-dose intermittent use — produces favorable shifts in the aging immune profile. The finding adds nuance to dosing strategy discussions in the longevity research community.

Bryan Johnson details the nine-protocol evening routine he says produces sleep performance in the 99.4th percentile. Key levers include a noon final meal, strict light management, and a multi-year system-building approach — not a single supplement stack.

A neuron-specific protein disposal system — the membranal proteasome — is directly tied to central hallmarks of Alzheimer's disease in a new study. Understanding why neurons rely on this unique clearance mechanism could open new targets for early-stage intervention.