Last updated June 22, 2026 — I read this morning's peptide research and picked the items that mattered. Fresh brief tomorrow.
Featured Briefs
UNDERSTANDING CAS NUMBERS IN PEPTIDE RESEARCH
Research VialsWhat CAS registry numbers are, why they matter for peptide identification, and how to use them to verify compound identity across suppliers.
SAFETY AND EFFICACY OF SWITCHING FROM DULAGLUTIDE TO TIRZEPATIDE ACROSS CLINICALLY RELEVANT BASELINE CHARACTERISTICS IN PARTICIPANTS WITH T2D: SUBGROUP ANALYSIS OF SURPASS-SWITCH.
PubMed · BMJ open diabetes research & careViolante-Ortiz R et al., BMJ open diabetes research & care · 2026 Mar 30. PMID 41912265.
OBESITY DRUGS BOOST TESTOSTERONE AND SPERM — NATURE BRIEFING REPORTS NEW DATA...
Nature BriefingNew data summarized by Nature suggests GLP-1 (glucagon-like peptide-1) drugs — the class that includes semaglutide and tirzepatide — may raise testosterone and improve sperm in obese men. The hormonal effects appear tied to fat loss, but researchers note the signal may be partly direct.
SENOLYTIC PROFILING STUDY MAPS IMMUNE, METABOLIC SHIFTS AFTER TREATMENT IN AGED MICE...
Nature AgingA new Nature Aging paper maps what happens at the molecular level after senolytic treatment in aged mice. Researchers found broad immune remodeling, reduced fibrosis markers, and improved metabolic signatures — filling in the 'how' behind senolytic benefits.
ANTIOXIDANTS SELECTIVELY CLEAR SENESCENT MUSCLE CELLS VIA mTOR PATHWAY...
Lifespan.ioAging Cell researchers found that antioxidants can selectively remove senescent muscle cells by altering mTOR (a nutrient-sensing pathway linked to aging). The finding points to a potential non-drug approach to clearing damaged cells from aging muscle tissue.
EPIGENETIC DRUG TARGETS PERIVASCULAR FAT, CUTS CARDIOMETABOLIC DISEASE MARKERS...
Lifespan.ioScientists targeted the thin fat layer wrapped around blood vessels using a transcription inhibitor and found reduced symptoms of cardiometabolic disease. The approach works by quieting inflammatory gene expression in a tissue that is usually very hard to reach with systemic drugs.
GIVE ME 15 MINUTES AND I'LL TELL YOU EVERYTHING YOUR DOCTOR DIDN'T ABOUT STARTING TRT
Biohacking SpecialistApply here to work 1:1 with me and my team: https://linktw.in/TQNxOy If you want to lose 30+ LBs, optimize your hormones and take your physique to the next level using and “enhanced blueprint, watch this video next: https://youtu.be/PjvW
THE CREATINE SCIENCE JUST GOT WAY MORE CRAZY
Thomas DeLauerSave up to 54% off Create's Creatine Gummies with Code TDLCREATE: http://trycreate.co/pages/thomas-fb Chris' Substack: https://chrismasterjohnphd.substack.com/ Mitochondrial Testing: https://www.mito.me/ This video does contain a paid par
THE REAL REASON TESAMORELIN DESTROYS VISCERAL FAT - DR TREVOR BACHMEYER
Dr Trevor BachmeyerTesamorelin Explained: Real Physiology, Correct Dosing, Water Retention Fixes, Sleep Solutions, and 5-Amino-1MQ Synergy I break down why tesamorelin isn’t growth hormone replacement but a GHRH analog that drives natural pulsatile GH releas
397 - ENDOMETRIOSIS AND ADENOMYOSIS: DIAGNOSIS, FERTILITY, REPRODUCTIVE AGING, & EMERGING TREATMENTS
Peter AttiaRenato Tomioka is a leading expert in reproductive medicine and gynecologic surgery whose unique skills allow him to diagnose and treat some of the most impactful yet frequently overlooked conditions affecting women’s health. In this episod
3 TRICKS TO EAT CARBS WITHOUT SPIKING BLOOD SUGAR (BACKED BY SCIENCE)
Dr Livingood🔥 Join thousands of people getting my weekly newsletter — packed with fat loss tips your doctor will never tell you! Click here to subscribe: https://content.livingooddaily.com/b37709 Most people think controlling blood sugar means giving
DR EXPLAINS WHY EVERYONE IS SUDDENLY TALKING ABOUT NAD
Dr Jones DCBook your free discovery call *HERE:* https://drjonesdc.com/yt1d NAD is suddenly everywhere: IV lounges, injections, oral precursors, longevity podcasts, and supplement shelves. I’m cutting through the hype and the backlash to explain why
DAILY TESTOSTERONE PROPIONATE VS CYPIONATE | TRT MICRODOSING EXPLAINED
Balance My HormonesMany TRT patients wonder whether daily testosterone injections provide better results than traditional protocols. In this video, we explore testosterone propionate, TRT microdosing, and the differences between subcutaneous (SubQ) and intram
DOES GONADORELIN INCREASE LIBIDO?
Regan ArchibaldLow libido can be frustrating and confusing, especially when I’m not sure whether hormones, lifestyle factors, or something deeper is causing the problem. In this video, I explore whether gonadorelin can increase libido by supporting the HP
IF I HAD INSULIN RESISTANCE AGAIN, I’D START DOING THIS TOMORROW
Thomas DeLauerJoin Thrive Market today and get $20 off your first three orders plus a free $60 gift! http://thrivemarket.com/ThomasDeLauer This video does contain a paid partnership with a brand that helps to support this channel. It is because of brand
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MITOCHONDRIAL-TARGETED PEPTIDES: THE NEXT RESEARCH FRONTIER
Research VialsMOTS-c, SS-31, and the emerging class of mitochondria-targeted peptides. How they work, what they target, and why mitochondrial medicine is growing.
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SKIP BREAKFAST OR EAT IT? THE ANSWER DEPENDS ON 1 THING
Thomas DeLauerGet LMNT Electrolytes & Receive a FREE Sample Flavors Pack: http://drinklmnt.com/thomas This video does contain a paid partnership with a brand that helps to support this channel. It is because of brands like this that we are able to provi
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WHY MOST PROSTATE SUPPLEMENTS FAIL (EVEN WHEN THE MARKETING SOUNDS GREAT)
Rena Malik MDIn this video, Dr. Rena Malik reviews prostate supplements like saw palmetto, beta-sitosterol, pygeum, pumpkin seed extract, lycopene, vitamin D, and more to explain which ones have real evidence, what they can and can’t do for enlarged pro
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SCIENCE OF ATTRACTION, COMPATIBILITY & ROMANCE | DR. PAUL EASTWICK
Andrew HubermanDr. Paul Eastwick, PhD, is a professor of psychology at the University of California, Davis, and a leading expert on the modern science of mate selection in humans. We discuss what people actually look for in a partner, including surprising
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PEPTIDES AND CANCER PART 1: HOW TUMORS HIJACK GROWTH PATHWAYS — RESEARCH VIALS DEEP DIVE...
Research VialsPart one of a three-part Research Vials series walks through the cell biology of cancer initiation and identifies which growth-signaling pathways tumors co-opt. It sets the foundation for understanding where peptides — both therapeutic and potentially risky — intersect with tumor biology.
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GH SECRETAGOGUES AND CANCER RISK: WHAT THE WASHOUT DATA ACTUALLY SAYS...
Research VialsPart three of the Research Vials cancer series takes on GH secretagogues — compounds like sermorelin, CJC-1295, and ipamorelin — and what researchers know about IGF-1 axis amplification, cancer risk, and washout timing. It's the most practically relevant installment for the performance-peptide community.
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SENESCENT CELLS FUEL TUMOR BLOOD VESSEL GROWTH — AGING CELL REVIEW...
Lifespan.ioA review published in Aging Cell links cellular senescence directly to vascular overgrowth around tumors. Senescent cells secrete factors that help cancers build their own blood supply — a mechanism that puts senolytic research squarely in the anti-cancer conversation.
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MELANOTAN PEPTIDES: MELANOCORTIN RESEARCH OVERVIEW
Research VialsResearch overview of Melanotan peptides — melanocortin receptor agonists studied for pigmentation pathways, photoprotection, and related endocrine signaling.
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PETER ATTIA ON ENDOMETRIOSIS: DIAGNOSIS, FERTILITY, AND EMERGING TREATMENTS...
Peter AttiaDr. Renato Tomioka joins Peter Attia to discuss endometriosis and adenomyosis — conditions that affect reproductive aging and fertility. Early diagnosis, says Tomioka, could prevent 40% of disease burden in young women. The episode covers emerging hormonal and surgical treatment options.
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CLINICAL AGING CLOCKS EVOLVE: FROM EPIGENETICS TO MULTI-OMICS INTEGRATION...
Aging CellA new Aging Cell review tracks how biological aging clocks have grown from simple DNA methylation readouts to integrated platforms combining epigenetic, proteomic, and metabolomic data. Multimodal clocks appear better at predicting disease risk than any single-layer approach alone.
- NATURE AGING CALLS FOR PRAGMATISM IN PRECLINICAL LONGEVITY RESEARCH... Nature Aging
- AGING DISRUPTS OVARIAN TIMING: SPATIAL COORDINATION BREAKS DOWN IN AGED MICE... Nature Aging
- NREM-LIKE BRAIN PATTERNS ARTIFICIALLY INDUCED IN MICE — SLEEP BENEFITS REPLICATED... Lifespan.io
- COMBINATION SENOLYTIC PLUS STEM CELL THERAPY ASSESSED IN AGED MOUSE MODEL... Fight Aging!