◤ Top story · Peter Attia
GLP-1 RAs AND MUSCLE LOSS: PETER ATTIA BREAKS DOWN THE NEW DATA...
*New readout suggests protein intake and resistance training nearly eliminate lean mass loss on GLP-1 drugs.*
Last updated July 4, 2026 — I read this morning's peptide research and picked the items that mattered. Fresh brief tomorrow.
Featured Briefs
◤ From the network · Research Vials
UNDERSTANDING CAS NUMBERS IN PEPTIDE RESEARCH
Research VialsWhat CAS registry numbers are, why they matter for peptide identification, and how to use them to verify compound identity across suppliers.
◤ Human study · PubMed
SAFETY AND EFFICACY OF SWITCHING FROM DULAGLUTIDE TO TIRZEPATIDE ACROSS CLINICALLY RELEVANT BASELINE CHARACTERISTICS IN PARTICIPANTS WITH T2D: SUBGROUP ANALYSIS OF SURPASS-SWITCH.
PubMed · BMJ open diabetes research & careViolante-Ortiz R et al., BMJ open diabetes research & care · 2026 Mar 30. PMID 41912265.
◤ Article
INTERMITTENT FASTING EXTENDS MALE MOUSE LIFESPAN 12% IN CONTROLLED STUDY...
Lifespan.ioAn 8-hour feeding window boosted median lifespan in male mice by 12%. Researchers note the gain may partly reflect voluntary caloric restriction — not fasting alone. The sex-specific finding adds nuance to blanket fasting claims.
◤ Article
STUDY MAPS APPROVED DRUGS TO HALLMARKS OF AGING — REPURPOSING CANDIDATES IDENTIFIED...
Lifespan.ioA network-based analysis matched existing approved drugs to the core hallmarks of aging. The method flags repurposing candidates without needing new molecules — a faster path than de novo drug development.
◤ Article
BRYAN JOHNSON'S 4 CARDIOVASCULAR PROTOCOLS: WHAT THE DATA SHOWS...
BluePrint (Bryan Johnson)Johnson details four lifestyle protocols that he credits with pushing his blood pressure below 90% of 18-year-olds. The piece pairs personal metrics with cited evidence — useful for separating the signal from the self-promotion.
◤ Article
PRIMATE-SPECIFIC RNA STRAND ACCELERATES CELLULAR SENESCENCE — NEW MECHANISM FOUND...
Lifespan.ioA newly identified non-coding RNA — found only in primates — worsens cellular senescence (the accumulation of dysfunctional cells that drives aging). The finding is relevant to human aging in ways that rodent models miss.
▶ Video
HOW TO REDUCE GUT INFLAMMATION | UNCOVER THE TRUTH
Dr Nick ZyrowskiGi Repair Formula Formula : http://bit.ly/2GmHKLs If you're wondering how to reduce gut inflammation, this video breaks down the science-backed strategies that can help calm the digestive tract, improve gut function, and support long-term
▶ Video
COULD YOUR SEMEN QUALITY PREDICT YOUR LIFESPAN? HERE'S WHAT YOU SHOULD KNOW
Rena Malik MDIn this episode, Rena Malik, MD brings together leading experts Dr. Helen Burney, Dr. James Smith, and Chief Medical Advisor of Swim Club Dr. Michael Eisenberg to discuss male infertility, declining sperm counts, and how lifestyle factors i
▶ Video
ACE-031 RESULTS FOR BODYBUILDING
Regan ArchibaldCurious about the results of using ACE-031 for bodybuilding? In this video, I break down the science behind ACE-031, exploring the human research on lean muscle growth, body composition, and strength, while also explaining why promising cli
▶ Video
MOST PEOPLE USE GLP 1S WRONG: HERE'S WHAT ACTUALLY WORKS (OZEMPIC, MOUNJARO, ETC.)
Dr Jones DCBook your free discovery call *HERE:* https://drjonesdc.com/yt1d Most people hit a GLP-1 plateau and assume the answer is a higher dose, but I see that backfire all the time. When appetite drops too low, food intake crashes, muscle loss s
▶ Video
DOCTOR EXPLAINS HOW DSIP PEPTIDE IMPROVES SLEEP, LOWERS STRESS & MORE (DSIP EXPLAINED)
Dr Jones DCBook your free discovery call *HERE:* https://drjonesdc.com/yt1d If you’re doing everything right for sleep and still waking up wrecked, the issue may not be total hours—it may be deep sleep. I explain how DSIP, or delta sleep-inducing pe
▶ Video
90 DAYS OF FULL CARNIVORE: NO PLANTS, NO FIBER, SURPRISING GUT RESULTS
Dave AspreyCarnivore Diet, Cholesterol, Gut Bacteria, Microbiome, and Fasting Insulin Results from a 90-Day Self-Experiment What if cutting out fiber entirely actually improved your gut bacteria? This episode breaks down a real 90-day carnivore sel
▶ Video · Peptide-anchored
IS BPC-157 GOOD FOR AFTER ACL SURGERY?
Regan ArchibaldCould BPC-157 help you recover faster after ACL surgery? In this video, let's examine the current research on BPC-157 and ACL reconstruction, while also discussing important safety considerations, FDA regulatory status, and why personalized
▶ Video · Peptide-anchored
GHK-CU SERUM: REAL-WORLD SKIN RESULTS!
The Enhanced ManDiscover the amazing benefits of GHK-Cu serum for your skin, a powerful anti-aging skincare solution that utilizes copper peptides to promote glowing skin and overall skin health. In this video, we'll be sharing real-world skin results from
▶ Video
WHY YOU'RE NOT LOSING FAT (4 HIDDEN MISTAKES YOU DON'T REALIZE YOU'RE MAKING)
Dr Livingood🔥 Join thousands of people getting my weekly newsletter — packed with fat loss tips your doctor will never tell you! Click here to subscribe: https://content.livingooddaily.com/b37709 Most people who lose fat gain it all back — and it's u
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MITOCHONDRIAL-TARGETED PEPTIDES: THE NEXT RESEARCH FRONTIER
Research VialsMOTS-c, SS-31, and the emerging class of mitochondria-targeted peptides. How they work, what they target, and why mitochondrial medicine is growing.
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SHE REGAINED COMPLETE SENSATION USING THIS METHOD
Dr Debra Durst🎯 What happens when women start losing sensation, arousal, or pleasure with age—and is there anything that can actually help? In this episode of The SexMD Podcast, Dr. Debra Durst sits down with sex educator, author, and podcaster Susan B
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ESCAPING THE HIGH-TAX WEST COAST FOR A BETTER LIFE | TAYLOR MASON
Dr Tyna MooreGet Strong with Me Inside my NEW Strength Vault: https://www.drtyna.com/offers/G33fSdvS/checkout EP. 269: Moving was one of the biggest decisions I've ever made, and honestly, one of the best. In this episode, I'm sitting down with my re
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LOW DOSE CIALIS (TADALAFIL): BIG BENEFITS BEYOND ED
Dr Michael MoellerTadalafil is one of the most underrated medications in men's health, and most of its benefits have nothing to do with what guys think it's for. In this video, Dr. Michael Moeller breaks down how Tadalafil (Cialis) works as a PDE5 inhibito
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THIS POWDER IS 2X STRONGER THAN CREATINE FOR PERFORMANCE (AND CHEAPER)
Thomas DeLauerUse code THOMAS at http://puori.com/THOMAS to get 32% off your first Puori Grass-fed Whey Protein order when you start a subscription! This video does contain a paid partnership with a brand that helps to support this channel. It is becaus
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WOLVERINE BLEND: WHAT THE BPC-157 + TB-500 COMBINATION RESEARCH ACTUALLY SHOWS...
Research VialsThe Wolverine Blend (BPC-157 paired with TB-500, the active fragment of Thymosin Beta 4) is one of the most-researched multi-peptide combinations. This reference piece maps the mechanistic overlap and the gaps still waiting for clinical confirmation.
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EPITALON VS N-ACETYL EPITALON AMIDATE: RESEARCHER'S GUIDE TO THE THREE FORMS...
Research VialsEpitalon (a telomerase-activating tetrapeptide) comes in three chemical forms with different stability and potency profiles. This guide breaks down what the structural differences mean for research design.
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CELL TYPE-SPECIFIC AGING CLOCKS PREDICT ALZHEIMER'S AND LUNG CANCER ONSET...
Lifespan.ioResearchers tracked aging trajectories in specific cell types and found they could predict disease onset for Alzheimer's and lung cancer. Cell-specific clocks outperform whole-blood measures for early-warning signal.
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MELANOTAN PEPTIDES: MELANOCORTIN RESEARCH OVERVIEW
Research VialsResearch overview of Melanotan peptides — melanocortin receptor agonists studied for pigmentation pathways, photoprotection, and related endocrine signaling.
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BIOLOGICAL AGING LINKED TO RISING EARLY-ONSET CANCER RATES ACROSS GENERATIONS...
Lifespan.ioA new study connects accelerated biological aging to the rise in solid cancers among adults under 50. Each generation shows a wider gap — suggesting upstream biological drift, not just lifestyle exposure.
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SENESCENT CELLS FOUND CONCENTRATED IN UV-CAUSED AGE SPOTS — PHOTOAGING MECHANISM CONFIRMED...
Fight Aging!Researchers confirmed that age spots (senile lentigo) contain a higher burden of senescent cells — the dysfunctional cells known to drive inflammation. The finding strengthens the case for senolytic and peptide-based skin repair strategies.
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REJUVENATION ROUNDUP JUNE 2026: THALION INITIATIVE, GENOMIC REPROGRAMMING, AND MORE...
Lifespan.ioLifespan.io's monthly summary covers the Thalion Initiative non-profit launch, advances in genomic-level aging interventions, and key papers from June. A useful single-read for researchers tracking the longevity field.
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BLOOD PROTEIN MAPPING CAN NOW ESTIMATE CELLULAR SENESCENCE BURDEN BY ORGAN...
Fight Aging!A machine-learning approach now maps organ-specific senescent cell burden from a single blood draw. This could become a practical readout for researchers tracking senolytic or peptide interventions over time.
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NEUROAGE THERAPEUTICS LAUNCHES YOUNGER 2027 — SIX-MONTH BIOLOGICAL AGE COMPETITION...
Lifespan.ioNeuroAge Therapeutics is running a six-month contest measuring participants on a clinical-grade aging panel at baseline and at six months. It's a real-world pressure test for longevity protocols — and a data collection exercise worth watching.
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METFORMIN FAILS IN PROSTATE CANCER — BUT EXCEPTIONS DEMAND PRECISION THINKING...
Peter AttiaPeter Attia reviews metformin's mixed cancer trial record and argues the failures don't close the door — they demand more precise patient selection. Directly relevant to longevity-drug-plus-cancer thinking.