PEP/NEWS — Peptide intel. Daily.

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If you're trying to understand the difference between stem cells and MUSE cells, it's easy to get overwhelmed by the claims and safety concerns. In this video, I explain how MUSE cells compare to traditional stem cells, the risks, FDA consi

In this edition of The Random Show, Tim Ferriss and Kevin Rose reunite over tequila to talk Zen retreats, learning to rock climb at (almost) 50, mortality and grief, why you should stop saying "one day," AI predictions , and much more. Plea

In this ⁠Huberman Lab Essentials⁠ episode, I explain the biology, symptoms and types of bipolar disorder (sometimes called bipolar depression), a condition characterized by extreme, maladaptive shifts in energy, mood and perception. I descr

A single epigenetic age reading gives a snapshot. New analysis shows that tracking how fast your epigenetic clock moves over time is a better predictor of mortality. This matters for researchers using peptides to shift aging biomarkers — the trajectory, not just the number, is the signal.

Disrupted calcium ion balance is a known hallmark of aging. Scientists found that fixing it with a well-known antidepressant significantly raised median and maximum lifespan in both progeroid and normally aging mice. The mechanism appears broadly relevant to cellular homeostasis research.

Restricting food to an 8-hour window extended median lifespan in male mice by 12%. Researchers note this may partly reflect voluntary caloric restriction rather than fasting timing itself. The sex-specific finding adds a variable worth tracking in metabolic peptide research.

A new review catalogs the many distinct triggers that push a cell into senescence — the state where it stops dividing but keeps secreting inflammatory signals (SASP). Understanding entry routes is essential for designing targeted senolytic and peptide-based interventions.

Sarcopenia (age-related muscle loss) and osteoporosis (bone loss) are linked by shared signaling pathways. Researchers have now mapped several of those connections. The findings are relevant to GH secretagogue and IGF-1 axis research targeting both muscle and skeletal health.