PEP/NEWS — Peptide intel. Daily.

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Andrew Huberman sits down with Tim Ferriss to cover peptides, performance optimization, and the research protocols underpinning his work at Stanford. A dense episode for anyone tracking how academic neuroscience is intersecting with applied peptide use.

Kate Tolo shares a detailed account of how she measured and reversed her skin biological age using multispectral imaging across eight skin markers. The protocol covers every intervention she used, with results tracked over time.

A new study finds that planned, structured exercise — not just general daily movement — protects against specific molecular markers of muscle aging. The distinction between planned training and general activity appears to matter for outcomes.

Gene editing startup Scribe raised $129 million in the first IPO of its kind in over two years. The raise is smaller than recent biotech debuts but marks a thaw in investor appetite for precision genomics.

Researchers used single-cell and spatially resolved transcriptomics to map the mouse thymus across aging. They found growing immunological heterogeneity and a shift in the direction of thymic selection — data that could inform immune restoration strategies.

Scientists engineered an enzyme that removes a specific AGE (advanced glycation end product, a sugar-modified protein that builds up with age and drives inflammation) from damaged proteins. Until now this class of modification was considered nearly impossible to reverse.

Younger mice ramp up autophagy (the cell's internal recycling process) when exposed to kidney toxins. Older mice cannot do the same, leaving them vulnerable to acute kidney injury. Researchers found that boosting autophagic flux through a targeted intervention reduced damage.

Researchers used exosomes from mesenchymal stem cells to counter metabolic liver damage in mice. The approach adds to a growing body of work on cell-derived signaling particles as an alternative to direct cell transplant.

A new review traces how epigenetic and proteomic aging clocks were built, what they can and cannot tell us about true biological age, and where the next generation of clocks may improve on current limits.

A Nature Aging perspective argues that TERT (the catalytic subunit of telomerase, which rebuilds chromosome end-caps) sits at a control point for multiple aging pathways — not just telomere length maintenance.

Lifelong dietary restriction of the amino acid valine improved health and extended lifespan in mice, but the benefits were stronger in one sex than the other. The findings add to mounting evidence that amino acid sensing pathways are key longevity levers.

Disrupting a specific inflammatory signaling axis improved function and reduced senescence-associated inflammation in aging mice and in models of chemotherapy-related damage. The finding has implications for both longevity and oncology recovery research.