PEP/NEWS — Peptide intel. Daily.

In this video, Dr. Rena Malik explains why the time it takes you to pee may reveal important clues about your bladder health. Learn why healthy mammals tend to empty their bladders in about 20 seconds, what a much longer or shorter stream c

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A new study found that regular planned exercise — not just general activity — protects against specific markers of muscle aging. The distinction between structured training and casual movement appears to matter more than previously thought.

A major review covers what biological aging clocks can and can't tell us. It maps the discoveries they enabled and points to where the next generation of clocks may go.

Researchers found that activating the GPR40 receptor delays aging of the thymus — the organ that produces T cells — in mice. The finding could point toward new immune-restoration strategies relevant to thymic peptide research.

Older mice don't ramp up autophagy — the cell's self-cleaning process — under toxic stress the way younger mice do. Forcing that ramp-up cut acute kidney injury in the older animals, opening a potential therapeutic angle.

Researchers used exosomes from mesenchymal stem cells to counter harmful metabolic changes in mouse livers. The approach adds to a growing body of work on cell-derived therapies for liver disease.

Scientists engineered an enzyme that removes advanced glycation end products (AGEs) — a form of protein damage that builds up with age — from proteins. AGE accumulation affects how proteins work and is linked to multiple age-related conditions.

The Health Optimisation Summit returns to London in September with a new business track for founders, investors, and clinicians. The event reflects growing commercial momentum around preventive and performance-focused health.

Experts argue the smartest nutrition strategy is simple: test first, supplement second. The piece pushes back on the growing market for untargeted supplement stacks and calls for a biomarker-guided approach.

Bryan Johnson's cardiovascular age measures younger than 90% of 18-year-olds by his own metrics. This breakdown covers four specific protocols he uses to target vascular function and blood pressure.

Lifelong restriction of the amino acid valine produced health and lifespan benefits in mice — but the effects differed significantly between males and females. The finding adds to work on dietary amino acid manipulation as a longevity lever.

Disrupting the CDK4/6–RARα–NF-κB axis reduced the inflammation that comes with cellular senescence and improved physical function in aged mice. It also showed benefit after chemotherapy — a dual-use finding with clinical implications.

New data show neutrophil extracellular traps (NETs) make UVB-induced skin damage significantly worse. The CCDC25/MAPK pathway is identified as the key mechanism — relevant context for photoaging and skin peptide research.