PEP/NEWS — Peptide intel. Daily.

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Andrew Huberman, Ph.D., is a neuroscientist and tenured professor in the Departments of Neurobiology and Ophthalmology at Stanford University School of Medicine, where he runs the Huberman Lab. He is the author of Protocols: An Operating Ma

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A real-world US cohort study found that prior GLP-1 RA (glucagon-like peptide-1 receptor agonist) use was linked to lower risk of sepsis-induced cardiomyopathy in type 2 diabetes patients. The finding adds to a growing list of cardioprotective signals from this drug class.

A new study found that planned, regular exercise — not just general daily movement — protects against specific epigenetic aging signatures in skeletal muscle. The distinction matters for anyone designing a longevity or performance protocol.

Researchers showed that neutrophil extracellular traps (NETs) — immune structures released during infection and stress — worsen UVB skin damage in mice. Blocking NETs reduced that damage, a finding relevant to photoaging and peptide-based skin repair research.

Kate Tolo shares a multi-year skin protocol validated by multispectral imaging across eight skin markers. The stack includes peptide-adjacent topicals alongside light and lifestyle interventions — with before/after data.

Researchers mapped how the titin N2A-MARP signaling complex limits longitudinal muscle growth during mechanical stretch. The finding clarifies a key pathway for muscle hypertrophy — relevant to anyone studying anabolic peptides and GH secretagogue effects on muscle tissue.

Attia's AMA #86 digs into the muscle loss question around GLP-1 receptor agonists (drugs like semaglutide used for weight loss). He argues that proper protein intake and resistance training dramatically reduce lean mass loss — and that the narrative around muscle wasting on these drugs needs nuance.

Researchers found that decoupling AMPK (a key energy-sensing enzyme) from fatty acid synthesis prevents late-life functional decline in yeast without restricting calories. The finding points to a potential metabolic target for preserving fitness in aging — relevant to AICAR and mitochondrial peptide research.

Johnson reports vascular function equivalent to someone in their late teens or early 20s. The four protocols he outlines include lifestyle, supplementation, and biomarker monitoring — with a data-first framing.

Part one of a three-part series on peptides and cancer biology. It covers how tumors form and which cellular signaling pathways they exploit — the foundation needed to evaluate peptide-based oncology research.