PEP/NEWS — Peptide intel. Daily.

In this video, Dr. Rena Malik explores what the research really says about women and pornography, why more women are watching porn than many people realize, and how their reasons for watching can influence sexual health, confidence, and rel

In this episode, Jim Otvos, Ph.D., recounts the unlikely story of transforming a flawed cancer test into a new way of measuring lipoproteins, explains what standard cholesterol tests can miss and why LDL-P and apoB can inform treatment deci

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Gladyshev Lab alumnus Dr. José Pedro Castro breaks down the inflammation-aging link. He covers where chronic low-grade inflammation fits into the broader aging picture and what the most promising intervention targets look like.

New research in Aging Cell shows that neutrophil extracellular traps (immune structures that normally fight infection) amplify UVB skin damage. Blocking them reduced injury in a mouse model — a finding with clear implications for photoaging research.

Planned, structured exercise — not just staying active — appears to reverse specific molecular aging markers in muscle tissue. The distinction between general activity and deliberate training matters more than previously thought.

Bryan Johnson claims he reversed significant hair loss between his late 20s and late 40s. His breakdown covers nutrition, topicals, and intervention timing — a practical look at aesthetic optimization with a self-experimenter's data behind it.

Attia reviews the latest data on GLP-1 receptor agonists (the class including semaglutide and tirzepatide) and lean mass loss during weight reduction. His takeaway: protein intake and resistance training largely close the gap when patients are properly counseled.

Researchers identified a titin-linked signaling complex (a stretch-sensing structure in muscle) that limits how much muscle grows in response to mechanical load. The finding opens a potential target for peptide-mediated hypertrophy research.

Separating AMPK (an enzyme that senses cellular energy) from fatty acid production preserved late-life fitness in yeast without calorie restriction. The mechanism may be relevant to metabolic peptide research targeting mitochondrial function.

Activating the lactate receptor GPR81 reduced hallmarks of cellular senescence and improved muscle function in progeroid aging models. It's an early-stage finding, but the pathway overlaps with areas where metabolic peptides are already being studied.